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Let the Mitochondria answer
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The mitochondria

This cellular organite present in all eukaryotic cells forms highly dynamic network composed of specialized compartments: the outer membrane, the intermembrane space, the inner membrane forming cristae and the matrix, site of metabolic reactions and mtDNA. Mitochondria play a major role in cell energy (ATP) production through respiratory chain located at the inner membrane and transform fuels and oxygen into CO2 and H2O to produce ATP.

In addition, mitochondria ensure key function in cell death control. Death-regulating proteins are localized at the outer membrane and provoke membrane permeabilization in response to death stimuli. This event is required for the release of pro-apoptotic molecules outside mitochondria and death signals induction. As mitochondrion controls the balance between life and death it is a critical target to look after during compound development.