The mitochondria

This cellular organite present in all eukaryotic cells forms highly dynamic network composed of specialized compartments: the outer membrane, the intermembrane space, the inner membrane forming cristae and the matrix, site of metabolic reactions and mtDNA. Mitochondria play a major role in cell energy (ATP) production through respiratory chain located at the inner membrane and transform fuels and oxygen into CO₂ and H₂O to produce ATP.

In addition, mitochondria ensure key function in cell death control. Death-regulating proteins are localized at the outer membrane and provoke membrane permeabilization in response to death stimuli. This event is required for the release of pro-apoptotic molecules outside mitochondria and death signals induction. As mitochondrion controls the balance between life and death it is a critical target to look after during compound development.