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2017

  • Chronic and low exposure to a pharmaceutical cocktail induces mitochondrial dysfunction in liver and hyperglycemia: differential responses between lean and obese miceBuron N, Porceddu M, Roussel C, Begriche K, Trak-Smayra V, Gicquel T, Fromenty B and Borgne-Sanchez A
    Env Toxicol. 32(4):1375-1389, Apr 2017

2015

  • Identification of drug-induced mitochondrial alterations using the HepaRG cell lineC. Pertuiset, M. Porceddu, N. Buron, S. Camus, C. Chesn and A. Borgne-Sanchez
    Toxicology Letters 238(2):S316-S317, Oct 2015
  • Mechanistic toxicity profiling of chemicals and nanomaterials by combining the ToxTracker genotoxicity assay and MiToxView mitochondrial toxicity platformG. Hendriks, R. Derr, M. Porceddu, N. Buron and A. Borgne-Sanchez
    Toxicology Letters 238(2): S298-S299, Oct 2015

2014

  • Mitochondrial dysfunctions in liver due to environmental drug contaminants and obesity, N. Buron, B. Fromenty and A. Borgne-Sanchez
    Toxicology Letters 229:S107, Sep 2014
  • A screening strategy to identify modulators of the mitochondrial ADP/ATP translocase (ANT) for cardioprotectionC. Nicolas, M. Porceddu, N. Buron, Z. Wang, C. Colas, B. Iorga, Y. Ambroise, G. Vandecasteele, R. Fischmeister, A. Borgne-Sanchez and C. Brenner
    Archives of Cardiovascular Diseases Supplements 6:58, Apr 2014
  • Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese micAnthrieu S, Le Guillou D, Coulouarn C, Begriche K, Trak-Smayra V, Martinais S, Porceddu M, Robin MA, Fromenty B
    Toxicol Appl Pharmacol. 276(1):63-72, Apr 2014

2013

  • Drug-induced inhibition of mitochondrial fatty-acid oxidation and steatosisMassart J., Begriche k., Buron N., Porceddu M., Borgne-Sanchez A. and Fromenty, B.
    Curr Pathol biol Rep. 1 (3):147-57, Sep 2013
  • Aftins increase amyloid-?42, lower amyloid-?38, and do not alter amyloid-?40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Hochard A, Oumata N, Bettayeb K, Gloulou O, Fant X, Durieu E, Buron N, Porceddu M, Borgne-Sanchez A, Galons H, Flajolet M and Meijer L.
    J Alzheimers Dis. 35(1):107-20, Aug 2013
  • Prediction of drug-induced liver injury in human with a multiparametric assay on the HepaRG cell lineN. Buron, M. Porceddu, C. Roussel, P. Rustin, S. Camus, B. Fromenty and A. Borgne-Sanchez
    Toxicology Letters 221:S157-S158, Aug 2013

2012

  • Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondriaPorceddu M, Buron N, Roussel C, Labbe G, Fromenty B and Borgne-Sanchez A
    Toxicol.Sci. 2012. 129(2):332-45, Oct 2012
  • HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidaseLecoeur H, Borgne-Sanchez A, Chaloin O, Buron N, Porceddu M, Rebouillat D, Langonn A, Brabant M, Pchoux C, Deniaud A, Brenner C, Briand JP, Muller S, Rustin P and Jacotot E
    Cell Death & Dis. 3: e282, Mar 2012

2011

  • Evaluation of drug-induced toxicity in isolated mouse liver mitochondria as a predictive model of hepatotoxicity risks in humanM. Porceddu, N. Buron, C. Roussel, B. Fromenty and A. Borgne-Sanchez
    Toxicology Letters 205:S537, Aug 2011
  • Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liverBegriche K, Massart J, Robin MA, Borgne-Sanchez A and Fromenty B
    J. Hepatol. 54(4):773-94, Apr 2011

2010

  • The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cellsGallerne C, Touat Z, Chen ZX, Martel C, Mayola E, Sharaf el dein O, Buron N, Le Bras M, Jacotot E, Borgne-Sanchez A, Lemoine A, Lemaire C, Pervaiz S and Brenner C
    IntJ Biochem Cell Biol. doi: 10.1016/j.biocel.2009.12.024, May 2010
  • Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-induced MOMPBuron N, Brabant M, Porceddu M, Desgu D, Racoeur C, Lassalle M, Rustin P, Pchoux C, Jacotot E and Borgne-Sanchez A
    PLoS One, 5(3): e9924, Mar 2010

2009

  • A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude miceBrabant M, Baux L, Casimir R, Briand JP, Chaloin O, Porceddu M, Buron N, Chauvier D, Lassalle M, Lecoeur H, Langonn A, Dupont S, Das O, Brenner C, Rebouillat D, Muller S, Borgne-Sanchez A, and Jacotot E
    Apoptosis. 14(10):1190-203, Oct 2009
  • Pharmacological screening and enzymatic assays for apoptosisBelzacq-Casagrande A-S, Martel C, Pertuiset C, Borgne-Sanchez A, Jacotot E and Brenner C
    Front Biosci. 14:3550-62, Jan 2009

2007

  • Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of αVβ3-expressing endothelial cellsBorgne-Sanchez A, Dupont S, Langonn A, Baux L, Lecoeur H, Chauvier D, Lassalle M, , Brire J-J, Brabant M, Roux P, Pchoux C., Briand J-P, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D and Jacotot E
    Cell Death Differ. 14:422-35, Mar 2007

2006

  • Therapeutic peptides: Targeting the mitochondrion to modulate apoptosisJacotot E, Deniaud A, Borgne-Sanchez A, Touat Z, Briand JP, Le Bras M and Brenner C
    Biochim Biophys Acta. 1757:1312-23, Sep 2006
  • Chemosensitization by knockdown of adenine nucleotide translocase-2Le Bras M, Borgne-Sanchez A, Touat Z, El Dein OS, Deniaud A, Maillier E, Lecellier G, Rebouillat D, Lemaire C, Kroemer G, Jacotot E and Brenner C
    Cancer Res. 66:9143-52, Sep 2006

2005

  • Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons. ApoptosisChauvier D, Lecoeur H, Langonn A, Borgne-Sanchez A, Mariani J, Martinou JC, Rebouillat D and Jacotot E
    Apoptosis. 10(6):1243-59, Dec 2005