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Let the Mitochondria answer
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On MiToxView models

• Isolated mitochondria from
       Normal human cell lines (HepaRG®)

• Cultured human cells
       Primary cells (Fibroblasts, Keratinocytes, PBMC)
       Normal human cells (HepaRG®)

For safety & seletion of cosmetic ingredients

  • Dermal toxicity
  • Systemic toxicity
  • Organ toxicity*

*Porceddu et al., Toxicol Sci., 2012.

 


Predictive toxicity assays

You are a cosmetic industry and you want to evaluate the toxicity of your ingredients in order to prevent toxicity for your customers.

You are looking for an in vitro alternative method.   

Mitologics highly predictive toxicity assays using platform are for you :

Starting Module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Swelling
        Transmembrane potential
        O2 consumption driven by complex I or II


• Short term (or metabolites) mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        ROS production

Premium module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Fatty acids ß-oxidation
        Complex (I-IV) enzymatic activity
        ROS production
        ATP production


• Long term mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        mtDNA quantification