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Let the Mitochondria answer
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On MiToxView models

• Isolated mitochondria from
    Rodent organs (Liver, Heart, Kidney)
    Normal human cell lines (HepaRG®)
    Tumor cell lines (Lung)

• Cultured human cells
    Primary cells (Fibroblasts, Keratinocytes, PBMC)
    iPS-derived cardiomyocytes (Cor.4U®)
    Normal cell lines (HepaRG®)
    Tumor cell lines (Lung)

For safety and selection of chemical substances

  • Dermal toxicity
  • Systemic toxicity
  • Organ toxicity*

*Porceddu et al., Toxicol Sci., 2012.

 

 




Predictive toxicity assays

You are a chemical industry or an agro-chemical industry and you want to evaluate the toxicity potential of your compounds that could trigger sever damages at the level of various organs such as liver, heart, kidney, ...

Mitologics highly predictive toxicity assays using platform are for you :

Starting Module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Swelling
        Transmembrane potential
        O2 consumption driven by complex I or II


• Short term (or metabolites) mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        ROS production

Premium module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Fatty acids ß-oxidation
        Complex (I-IV) enzymatic activity
        ROS production
        ATP production


• Long term mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        mtDNA quantification