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Let the Mitochondria answer
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On MiToxView models

• Isolated mitochondria from
    Rodent organs (Liver, Heart, Kidney)
    Differentiated human cells (HepaRG®)

• Cultured human cells
    Primary cells (Hepatocytes, Fibroblasts, PBMC)
    iPS-derived cardiomyocytes (Cor.4U®)
    Hepatic stem cell line (HepaRG®)

For preclinical studies

  • Hepatoxicity (80% predictivity)*
  • Cardiotoxicity
  • Nephrotoxicity

*Porceddu et al., Toxicol Sci., 2012.


Predictive toxicity assays

You are a pharmaceutical industry or a biotechnology company and you want to evaluate the toxicity potential of your drugs or your compounds prior to enter into preclinical regulatory stage.

Mitologics highly predictive toxicity assays using platform are for you :

Starting Module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Swelling
        Transmembrane potential
        O2 consumption driven by complex I or II


• Short term (or metabolites) mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        ROS production

Premium module

• Acute/direct mitochondrial toxicity (on isolated mitochondria)
        Fatty acids ß-oxidation
        Complex (I-IV) enzymatic activity
        ROS production
        ATP production


• Long term mitochondrial toxicity (on cultured cells)
        Viability or whole ATP content
        Transmembrane potential
        Global respiration
        mtDNA quantification