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Let the Mitochondria answer
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On MitoXpert models

• Isolated mitochondria from :
    Healthy or pathological rodent organs
    Normal cell lines
    Tumor cell lines

• Cultured human cells
    iPS-derived cardiomyocytes
    Normal cell lines
    Tumor cell lines
    Patients-derived cell lines

For discovery/potency assays

  • Cardioprotection
  • Neuroprotection
  • Organ transplantation
  • Metabolic diseases
  • Mitochondrial diseases

Mitochondrial efficacy assays

You are a pharmaceutical industry or a biotechnology company  and you want to identify mitochondrial targeting properties of your compounds.

Mitologics mitochondrial efficacy assays using  platform are for you :

Module I. Protection

  • mPTP targeting
    • Protection from Ca-induced swelling    
  • MitoK ATP-dependent channel targeting
    • Induction of MitoK channel opening
  • Bax/Bak pore
    • Protection from cytochrome c release
  • Oxidative stress
    • Protection from ROS production

on healthy mitochondrial models

Module 2. Recovery

• O2 consumption driven by Complex I or II or FAO
• Complex (I-V) enzymatic activity
• ATP production
• Mitochondrial network
• mtDNA quantification